| 李铁教授化湿解毒法治疗干燥综合症的用药研究 |
| A Study on the Use of Professor Li Tie"s Dampness-Resolving and Detoxification Method in the Treatment of Sjögren"s Syndrome |
| DOI： |
| 中文关键词: 干燥综合症 中药 用药规律 |
| 英文关键词: Sjögren"s syndrome Traditional Chinese medicine Medication rules |
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| 中文摘要: |
| 目的:基于中医传承计算平台(V3.5)探析李铁教授化湿解毒法治疗干燥综合症的用药研究,为其临床治疗提供参考。方法:收集2013年1月—2021年12月就诊于大连市第二人民医院、盛京医院大连医院、大连市旅顺口区中医医院、大连市金州区中医医院李铁教授传承工作室门诊,且符合干燥综合征诊断标准的患者病历完整的100例,共统计100张处方,运用中医传承计算平台(V3.5)建立药物数据库,对中药进行使用频率统计分析、性味归经及药物功效分析、关联规则分析和聚类分析。结果:符合纳入标准处方100首,共使用中药188味,其中排名前10位的分别为半枝莲、野菊花、玄参、生地、麦冬、太子参、土茯苓、白花蛇舌草、沙参、炒白芍;常用药物四气分布中,寒性药使用最多,五味分布中,苦味药使用最多,归经分布中,肺经药使用最多,药物功效分类中,清热类使用最多;药物关联规则前5位的依次为:半枝莲、玄参-野菊花,白花蛇舌草-土茯苓,半枝莲、太子参-野菊花,野菊花-半枝莲,野菊花、生地-半枝莲;聚类分析共得到3组药物聚类组合。结论:李铁教授在诊治干燥综合征时注重三焦同治,强调养阴生津同时兼顾化湿解毒。 |
| 英文摘要: |
| Objective: Based on the Traditional Chinese Medicine Inheritance Calculation Platform (V3.5), this study aims to explore Professor Li Tie"s medication research on the treatment of Sj?gren"s syndrome with the method of resolving dampness and detoxifying, providing a reference for its clinical treatment. Methods: A total of 100 cases of complete patient medical records who visited the outpatient clinics of Professor Li Tie"s Inheritance Studio in Dalian Second People"s Hospital, Shengjing Hospital Dalian Branch, Dalian Lushunkou District Traditional Chinese Medicine Hospital, and Dalian Jinzhou District Traditional Chinese Medicine Hospital from January 2013 to December 2021 and met the diagnostic criteria for Sj?gren"s syndrome were collected. A total of 100 prescriptions were analyzed, and a drug database was established using the Traditional Chinese Medicine Inheritance Calculation Platform (V3.5). The analysis included the statistical analysis of drug usage frequency, analysis of drug properties, flavors, meridians, and functions, as well as analysis of association rules and clustering. Results: A total of 100 prescriptions meeting the inclusion criteria were analyzed, using 188 kinds of Chinese medicines. The top 10 medicines used were Barbed Skullcap, Wild Chrysanthemum, Radix Scrophulariae, Raw Radix Rehmanniae, Dwarf Lilyturf Tuber, Pseudostellaria Root, Tuckahoe, Hedyotis Diffusa, Adenophora Root, and Prepared White Peony Root. Among the commonly used drugs, cold-natured drugs were the most used, and bitter-flavored drugs were the most common in the five flavors. Lung meridian drugs were the most used in the meridian distribution, and heat-clearing drugs were the most used in the drug function classification. The top five drug association rules were: Barbed Skullcap, Radix Scrophulariae-Wild Chrysanthemum, Hedyotis Diffusa-Tuckahoe, Barbed Skullcap, Pseudostellaria Root-Wild Chrysanthemum, Wild Chrysanthemum-Barbed Skullcap, Wild Chrysanthemum, Raw Radix Rehmanniae-Barbed Skullcap. Cluster analysis yielded three groups of drug combinations. Conclusion: Professor Li Tie focuses on treating Sj?gren"s syndrome with the method of resolving dampness and detoxifying, emphasizing nourishing yin and promoting saliva production while considering resolving dampness and detoxifying. |
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