| 郁证与不寐的中医学关系：一项两样本双向孟德尔随机化研究 |
| The traditional Chinese medicine relationship between depression and insomnia: a two-sample bidirectional Mendelian randomization study |
| DOI： |
| 中文关键词: 孟德尔随机化 中医 郁证 不寐 因果关系 |
| 英文关键词: Mendelian Randomization (MR) Traditional Chinese Medicine Depression Insomnia Causality |
| 基金项目:福建中医药大学附属人民医院第二批医院科研团队建设项目（编号：创新团队-02） |
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| 中文摘要: |
| 目的：采用两样本双向孟德尔随机化(MR)研究中医郁证与不寐的因果关系。方法：从全基因组关联研究数据库中下载并筛选与郁证及不寐强相关的单核苷酸多态性(SNPs)作为工具变量；利用逆方差加权法、MR-Egger、加权中位数法、简单模式法和加权模式法分析郁证与不寐间的因果关系；通过Cochran"s Q、MR-Egger截距、留一法、漏斗图对结果进行敏感性分析,评估研究结果的可靠性和稳定性。结果：经筛选后,共获得12个与郁证强相关的SNPs用于正向MR分析,结果显示,郁证会明显增加不寐的发病风险(OR=1.423,95% CI：1.201~1.684,P=0.001)；共获得39个与不寐强相关的SNPs用于反向MR分析,结果显示,不寐会明显增加郁证的发病风险(OR=1.207,95% CI：1.137~1.281,P=0.001)。敏感性分析显示,双向结果均存在异质性(P＜0.05),均不存在水平多效性(P＞0.05)。结论：郁证与不寐间存在互为因果的双向关系,本次研究结果稳健,结论可靠。 |
| 英文摘要: |
| Objective: To investigate the causal relationship between depression and insomnia using two-sample bidirectional Mendelian randomization (MR). Methods: Firstly, single nucleotide polymorphisms (SNPs) strongly associated with depression and insomnia were selected from the genome-wide association study database as instrumental variables. Secondly, inverse variance weighting method, MR-Egger, weighted median method, simple model method and weighted model method were used to analyze the causal relationship between depression and insomnia. Finally, sensitivity analysis of the results was carried out through Cochran"s Q, MR-Egger intercept, leave one method and funnel plot to evaluate the reliability and stability of the results. Results: After screening, 12 SNPs strongly correlated with depression were obtained. MR Results showed that depression significantly increased the risk of insomnia (OR=1.423, 95% CI: 1.201~1.684, P=0.001). As well as, 39 SNPs strongly associated with insomnia were obtained, and MR Results showed that insomnia significantly increased the risk of depression (OR=1.207, 95% CI: 1.137~1.281, P=0.001). Sensitivity analysis showed that both results had heterogeneity (P＜0.05) and no horizontal pleiotropy (P＞0.05).Conclusion: There is a mutual causal relationship between depression and insomnia. The results of this study are robust and the conclusion is reliable. |
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