| 肾络育春丸治疗肾阴虚痰瘀交阻型多囊卵巢综合征的临床观察 |
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| DOI： |
| 中文关键词: 多囊卵巢综合征 肾络育春丸 肾阴虚痰瘀交阻型 二甲双胍 临床观察 |
| 英文关键词: Polycystic ovary syndrome Shenluo Yu Chun Pills(肾络育春丸) Kidney-yin deficiency and phlegm-bloodstasis type Metformin Clinical observation |
| 基金项目:上海市卫生健康委员会中医药科研项目 编号2022QN105 |
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| 中文摘要: |
| 目的 观察肾络育春丸治疗肾阴虚痰瘀交阻型多囊卵巢综合征的临床疗效。方法 将52例肾阴虚痰瘀交阻型多囊卵巢综合征患者按2:1比例随机分为治疗组(36例)与对照组(16例)。分别予肾络育春丸、二甲双胍口服治疗,观察治疗后排卵率、临床症状、体征以及血生殖内分泌、糖代谢相关指标的变化。结果 治疗组、对照组周期排卵率分别为70.83%、56.14%,治疗组疗效优于对照组(P＜0.05)；治疗组在改善患者月经情况及口干等全身症状方面疗效优于对照组(P＜0.01或0.05)；治疗后两组患者BMI均明显下降(P＜0.01或0.05),但组间无明显差异(P＞0.05)；治疗组WHR明显下降(P＜0.05)；治疗组在治疗后血睾酮及硫酸脱氢表雄酮水平明显下降(P＜0.01或0.05),对照组血睾酮水平明显下降(P＜0.05),两组间无明显差异(P＞0.05)。两组患者胰岛素抵抗指数(HOMA-IR)均有明显下降(P＜0.01),对照组效果更明显(P＜0.05)。结论 肾络育春丸可改善肾阴虚痰瘀交阻型多囊卵巢综合征患者的临床症状、体征,降低雄激素及胰岛素抵抗,从而提高排卵率。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of “Shenluo Yu Chun Pills” in the treatment of polycystic ovary syndrome (PCOS) of the kidney yin deficiency with phlegm-stasis intermingling type. Methods A total of 52 PCOS patients with kidney yin deficiency and phlegm-stasis intermingling type were randomly divided into the treatment group (36 cases) and the control group (16 cases) at a ratio of 2:1. The treatment group was administered Shenluo Yu Chun Pills orally, while the control group received metformin orally, with a treatment course of 6 months. Changes in ovulation rate, clinical symptoms, signs, and blood indicators related to reproductive endocrine and glucose metabolism were monitored after treatment. Results The ovulation rates of the treatment group and the control group were 70.83% and 56.14% respectively, with the treatment group demonstrating superior efficacy (P＜0.05). The treatment group was more effective than the control group in improving menstrual cycle, menstrual flow, menstrual color, dry mouth, and other systemic symptoms (P＜0.01 or 0.05). BMI significantly decreased in both groups after treatment (P＜0.01 or 0.05), but no significant intergroup difference was observed (P＞0.05). Waist-to-hip ratio (WHR) of the treatment group decreased significantly (P＜0.05), whereas that of the control group showed no significant change (P＞0.05). Serum testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) in the treatment group decreased significantly (P＜0.01 or 0.05), though serum T in the control group also decreased significantly (P＜0.05), but there was no significant difference between the two groups (P>0.05). The insulin resistance index (HOMA-IR) of both groups showed significant decreases (P<0.01), with a more prominent reduction in the control group (P＜0.05). Conclusion Shenluo Yu Chun Pills can improve the clinical symptoms and signs of PCOS patients with kidney yin deficiency and phlegm-stasis intermingling group, reduce androgens and insulin resistance, thereby enhancing the ovulation rate. |
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