| STING信号通路与抑郁症的关联及中药干预研究进展 |
| The Association of STING Signaling Pathway with Depression and Advances in Traditional Chinese Medicine Intervention Research |
| DOI： |
| 中文关键词: STING 抑郁症 神经炎症 中药 小分子 |
| 英文关键词: STING Depression Neuroinflammation Traditional Chinese Medicine Small Molecules. |
| 基金项目:基于色氨酸/AHR/SLC7A5环路驱动小胶质/巨噬细胞极化探讨交泰丸改善糖尿病抑郁障碍的机制,国家自然科学基金项目（面上项目，重点项目，重大项目） |
|
| 摘要点击次数: |
| 全文下载次数: |
| 中文摘要: |
| 抑郁症作为一种常见且致残率高的情绪障碍性疾病,表现为负面情绪、认知功能障碍及躯体症状,严重影响全球公共健康。尽管当前的治疗手段包括抗抑郁药和心理疗法,但疗效有限,部分患者出现耐药性,亟需新的治疗策略。STING信号通路在先天免疫和炎症反应中的作用受到广泛关注,已有研究表明其异常激活与抑郁症发病机制相关。本文综述了STING在抑郁症中的作用机制,探讨其作为治疗靶点的可能性,尤其评估了中药通过多成分和多靶点优势调节STING通路的潜力,为抑郁症提供了新颖的干预思路及未来的研究方向。 |
| 英文摘要: |
| Depression, a prevalent and highly disabling mood disorder, manifests as negative emotions, cognitive impairment, and somatic symptoms, severely impacting global public health. Although current treatments, including antidepressants and psychotherapy, are diverse, their effectiveness remains limited, and some patients develop resistance, creating an urgent need for novel therapeutic approaches. The STING signaling pathway, recognized for its role in innate immunity and inflammatory responses, has gained widespread attention. Studies have shown that its abnormal activation is associated with the pathogenesis of depression. This paper reviews the mechanisms by which STING contributes to depression and explores its potential as a therapeutic target, particularly focusing on the advantages of Traditional Chinese Medicine (TCM) in modulating the STING pathway through multi-component, multi-target actions. This review provides innovative intervention insights and future research directions for the treatment of depression. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|