| 基于“缺氧—线粒体—肠心轴”共调控网络的心力衰竭铁死亡机制与中医药防治 |
| Mechanism and TCM Prevention of Heart Failure Ferroptosis Based on the "Hypoxia-Mitochondria-Gut-Heart Axis" Co-regulatory Network |
| DOI： |
| 中文关键词: 心力衰竭 铁死亡 缺氧 线粒体铁稳态 肠—心代谢 中医药 |
| 英文关键词: Heart failure Ferroptosis Hypoxia Mitochondrial iron homeostasis Gut-heart metabolism Traditional Chinese Medicine (TCM) |
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| 中文摘要: |
| 心力衰竭是多种心血管疾病发展的终末阶段,发病率和死亡率逐年攀升。近年来,铁死亡作为一种依赖铁和脂质过氧化的程序性细胞死亡方式,在心力衰竭的病程中备受关注。铁死亡不仅涉及铁代谢紊乱和谷胱甘肽过氧化物酶4功能失活,还与缺氧、线粒体铁稳态、肠—心代谢轴密切相关。中药以其多成分、多靶点优势,能够在改善组织缺氧、保护线粒体功能及调节肠道微生态等方面展现出巨大潜力,为心力衰竭治疗提供新思路。本文系统综述了铁死亡在心力衰竭中的最新研究进展,重点讨论缺氧、线粒体铁稳态及肠—心代谢轴的前沿发现,并总结了中药干预的证据与潜在机制,旨在为未来基础研究和临床转化提供参考。 |
| 英文摘要: |
| Heart failure (HF) is a major global health burden. Recently, ferroptosis, an iron-dependent regulated cell death, has emerged as a pivotal mechanism in HF pathogenesis. Mechanism: Ferroptosis in HF is regulated by a multidimensional network involving hypoxia, mitochondrial homeostasis, and the gut-heart axis. Hypoxia exacerbates iron uptake via HIF signaling; mitochondrial dysfunction drives ROS accumulation; and gut-derived metabolites (e.g., TMAO) remotely sensitize cardiomyocytes to oxidative stress. Scope: This review analyzes the crosstalk within this "Hypoxia-Mitochondria-Gut-Heart" axis and systematically evaluates the therapeutic potential of Traditional Chinese Medicine (TCM). Results: Evidence suggests that TCM interventions effectively inhibit ferroptosis by ameliorating the hypoxic microenvironment, restoring mitochondrial iron/energy homeostasis, and reshaping gut microbiota to reduce toxic metabolites. Conclusion: Targeting the "Hypoxia-Mitochondria-Gut-Heart" axis offers a novel integrative strategy for HF treatment, highlighting the clinical potential of TCM in regulating ferroptosis。 |
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