| 湿润烧伤膏治疗肛周克罗恩病型肛瘘术后创面的临床疗效观察 |
| Observation on the Clinical Efficacy of Moist Exposed Burn Ointment (MEBO) in the Treatment of Postoperative Wounds in Patients with Perianal Fistulizing Crohn''s Disease |
| DOI： |
| 中文关键词: 湿润烧伤膏 肛周克罗恩病型肛瘘 术后 创面 临床观察 |
| 英文关键词: Moist Exposed Burn Ointment perianal fistulizing Crohn’s disease postoperative wound clinical observation. |
| 基金项目:2025年度湖北省科技厅中医药创新发展联合基金重点项目（编号：2025AFD475） |
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| 中文摘要: |
| 【目的】探讨湿润烧伤膏治疗肛周克罗恩病型肛瘘术后创面的临床疗效。 【方法】选取2023年6月至2025年5月湖北省中医院(湖北中医药大学附属医院)光谷院区收治的肛周克罗恩病型肛瘘患者共计82例,按随机数字表法分成观察组和对照组,每组41例。两组患者均由导师本人主刀手术,术后控便48h,第一次排便后每日均予以院内制剂痔科消炎止痛洗剂坐浴15min,常规生理盐水清洁创面,对照组予以凡士林纱条填塞创面,观察组予以湿润烧伤膏纱条填塞创面,观察周期为2个月。观察、对比两组患者创面肉芽生长质量、创面渗液情况、疼痛水肿评分以及炎症因子水平。【结果】(1)观察组临床治疗总有效率为92.7%,很明显高于对照组的有效率的80.5%,差异有统计学意义(P＜0.05);治疗2周后,观察组肉芽组织生长质量评分优于对照组,差异有统计学意义(P＜0.05)。(2)治疗后,观察组创面渗液半定量评分明显低于对照组,差异有统计学意义(P＜0.05)。(3)观察组创面炎症因子水平,疼痛、水肿评分均低于对照组,差异具有统计学意义(P＜0.05) 。【结论】在肛周克罗恩病型肛瘘术后创面的修复上,湿润烧伤膏的应用可以更有效的提高该类创面的愈合速度,减轻患者术后创面疼痛、水肿以及炎症情况,加速创面的健康愈合。 |
| 英文摘要: |
| [Objective]?This study aims to investigate the clinical efficacy of Moist Exposed Burn Ointment (MEBO) in the treatment of postoperative wounds in patients with perianal fistulizing Crohn''s disease. [Methods]?A total of 82 patients with perianal fistulizing Crohn''s disease,treated at the Guanggu Campus of Hubei Provincial Hospital of Traditional Chinese Medicine between June 2023 and May 2025 were selected and randomly divided into an observation group and a control group, with 41 patients in each group. Both groups underwent surgery performed by the same supervisor. Postoperatively, bowel movements were controlled for 48 hours. After defecation, all patients received 15-minute sitz baths with the hospital-prepared anti-inflammatory and analgesic lotion for hemorrhoids, followed by wound cleaning with normal saline. The control group was treated with Vaseline gauze for wound packing, while the observation group was treated with MEBO gauze. Dressing changes were performed until wound healing was achieved. The quality of granulation tissue growth, wound exudate levels, pain and edema scores, and inflammatory cytokine levels were observed and compared between the two groups.[Results](1) The total clinical effective rate in the observation group was 92.7%, significantly higher than the 80.5% in the control group, with a statistically significant difference (P＜0.05). After two weeks of treatment, the granulation tissue growth quality score in the observation group was superior to that of the control group, with a statistically significant difference (P＜0.05).(2) After treatment, the semi-quantitative wound exudate score in the observation group was significantly lower than that in the control group, with a statistically significant difference (P＜0.05).(3) The levels of inflammatory cytokines, as well as pain and edema scores, in the observation group were lower than those in the control group, with statistically significant differences (P＜0.05).[Conclusion]?In the repair of postoperative wounds in patients withperianal fistulizing Crohn’s disease, MEBO gauze can more effectively enhance wound healing speed, reduce postoperative pain, edema, and inflammation, and promote rapid wound healing. |
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