| 基于“肠道菌群-线粒体自噬”探讨“从脾论治”动脉粥样硬化 |
| Discussion on atherosclerosis from the perspective of spleen based on "gut flora-mitochondrial autophagy" |
| DOI： |
| 中文关键词: 动脉粥样硬化 肠道菌群 线粒体自噬 从脾论治 脾虚 |
| 英文关键词: atherosclerosis intestinal flora Mitochondrial autophagy From spleen theory to treatment insufficiency of the spleen |
| 基金项目:国家自然科学基金青年科学基金项目（81703970）； 辽宁省自然科学基金优秀青年基金计划项目（2023JH3/10200016） |
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| 中文摘要: |
| 摘要:按照中医理论体系来讲“脾脏”功能意义重大，它和肠道内菌群的结构有紧密联系还与线粒体自噬的过程息息相关，脾脏功能虚弱时肠道菌群容易失衡线粒体自噬功能也会紊乱。这就使得机体内部清理机制的效能降低代谢废物持续累积，这一连串变化必然会加快或者加重AS的病理演变。中医学注重整体协调平衡，在调整肠道菌群构成这件事上在提升线粒体自噬效能方面中医学都凸显出独特优势，本研究选取“脾脏-肠道菌群-线粒体自噬”这一全新视角。在此视角下，深入剖析AS的发病机理，这一做法意义重大一方面加深了中医对于通过调理脾脏来治疗现代疾病的认知，另一方面为运用中药防治AS开拓了新思路还给出了坚实的理论依据。 |
| 英文摘要: |
| Abstract：In traditional Chinese medicine (TCM) theory, the spleen plays a pivotal role in bodily functions. Its structure is closely linked to gut microbiota and intracellular mitochondrial autophagy processes. When spleen function weakens, intestinal flora becomes imbalanced while mitochondrial autophagy mechanisms malfunction. This impairs the body''s internal detoxification capacity, causing metabolic waste to accumulate continuously. Such pathological changes inevitably accelerate or exacerbate AS. TCM emphasizes holistic coordination and balance, demonstrating unique advantages in regulating gut microbiota composition and enhancing mitochondrial autophagy efficiency. This study adopts a novel perspective of "spleen-gut microbiota-mitophagy" to thoroughly analyze AS pathogenesis. This approach holds significant importance: it deepens TCM''s understanding of modern disease treatment through spleen regulation, while pioneering new therapeutic strategies for AS prevention using herbal medicine with solid theoretical foundations. |
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