| 艾烟熏灸干预膝骨性关节炎（肿胀型）前瞻性队列研究 |
| Prospective cohort study of moxa smoked moxibustion intervention in knee osteoarthritis ( swelling type ) |
| DOI： |
| 中文关键词: 艾烟熏灸 膝骨性关节炎 肿胀型 疗效 |
| 英文关键词: Moxa Smoked Moxibustion Knee Osteoarthritis Swelling Type Curative Effect |
| 基金项目:江西省中医药管理局科技计划(2024B0523) |
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| 中文摘要: |
| 目的：观察艾烟熏灸治疗膝骨性关节炎（knee osteoarthritis, KOA）肿胀型患者的临床疗效。方法： 选择2023年6月至2025年6月在我院接受治疗的KOA肿胀型患者为研究对象，采用前瞻性队列研究的试验设计，暴露组与非暴露组按1:1进行分组，预计各纳入54例，再考虑10%失访率，每组60例，共纳入120例患者。非暴露组接受常规针灸配合药物治疗，暴露组在常规治疗基础上接受艾烟熏灸治疗，两组均连续治疗4周。比较两组的临床疗效、中医证候积分、特种外科医院膝关节评分（hospital for special surgery knee score, HSS）、西安大略和麦克马斯特大学骨关节炎指数（western ontario and mcmaster universities osteoarthritis index, WOMAC）、疼痛评分指标（visual analog scale, VAS）及血清炎症指标[超敏C反应蛋白（high-sensitivity C-reactive protein, hs-CRP）、肿瘤坏死因子-α（tumor necrosis factor-α, TNF-α）、白细胞介素-6（Interleukin-6, IL-6）、白细胞介素-17（Interleukin-17, IL-17）、红细胞沉降率（erythrocyte sedimentation rate, ESR）、白细胞计数（white blood cell count, WBC）、血小板计数（platelet count, PLT）]水平以及不良反应。结果： 暴露组的总有效率高于非暴露组（P＜0.05）。治疗后，暴露组的中医证候积分、WOMAC评分与VAS评分均低于非暴露组（P＜0.05），HSS评分高于非暴露组（P＜0.05）。治疗后，暴露组的hs-CRP、TNF-α、IL-6、IL-17、ESR、WBC、PLT水平均低于非暴露组（P＜0.05）。两组患者在治疗过程中均无明显的不良反应发生，治疗安全性均较好。结论： 艾烟熏灸对KOA肿胀型患者的临床疗效显著，能够有效改善其临床症状，提高膝关节功能，减轻疼痛程度，降低炎症反应，且安全性较高。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy of moxa smoked moxibustion in the treatment of knee osteoarthritis ( KOA ) patients with swelling type.Method: The patients with KOA swelling type who were treated in our hospital from June 2023 to June 2025 were selected as the research objects. The experimental design of prospective cohort study was adopted. The exposure group and the non-exposure group were grouped according to 1 : 1, and 54 cases were expected to be included in each group. Considering the 10 % loss of follow-up rate, 60 cases in each group, a total of 120 patients were included. The non-exposed group received routine acupuncture combined with drug treatment, and the exposed group received moxa smoked moxibustion on the basis of routine treatment. Both groups were treated continuously for 4 weeks. The clinical efficacy, TCM syndrome score, hospital for special surgery knee score ( HSS ), Western Ontario and McMaster Universities Osteoarthritis Index ( WOMAC ), pain score index ( VAS ) and serum inflammatory indexes [ high-sensitivity C-reactive protein ( hs-CRP ), tumor necrosis factor-α ( TNF-α ), interleukin-6 ( IL-6 ), interleukin-17 ( IL-17 ), erythrocyte sedimentation rate ( ESR ), white blood cell count ( WBC ), platelet count ( PLT ) ] and adverse reactions, were compared between the two groups.Results： The total effective rate of the exposed group was higher than that of the non-exposed group ( P < 0.05 ). After treatment, the TCM syndrome score, WOMAC score and VAS score of the exposed group were lower than those of the non-exposed group ( P < 0.05 ), and the HSS score was higher than that of the non-exposed group ( P < 0.05 ). After treatment, the levels of hs-CRP, TNF-α, IL-6, IL-17, ESR, WBC and PLT in the exposed group were lower than those in the non-exposed group ( P < 0.05 ). Conclusions： The clinical effect of moxibustion on KOA patients with swelling type is significant. It can effectively improve the clinical symptoms, improve the function of knee joint, reduce the degree of pain, reduce the inflammatory reaction, and has high safety. |
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